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Aging Research
Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice
Wang, D., Yang, Y., Zou, X., Zhang, J., Zheng, Z. & Wang, Z. J Gerontol A Biol Sci Med Sci. 2020. 75 (11): 2081-2088.

Assays under Hypoxia
Cardioprotection by isosteviol derivate JC105: A unique drug property to activate ERK1/2 only when cells are exposed to hypoxia-reoxygenation
Mohammed Abdul, K. S., Rayadurgam, J., Faiz, N., Jovanovic, A. & Tan, W. J Cell Mol Med. 2020. 24 (18): 10924-10934.

Cancer Research
Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells
Dey, P., Kundu, A., Han, S. H., Kim, K. S., Park, J. H., Yoon, S., Kim, I. S. & Kim, H. S. Biomolecules. 2020. 10 (9): 

A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth
Fu, R., Yang, P., Amin, S. & Li, Z. Biochem Biophys Res Commun. 2020. 531 (4): 465-471.

Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p
Chen, L., Chi, K., Xiang, H. & Yang, Y. Cancer Manag Res. 2020. 12 9965-9976.

Novel ginsenoside derivative 20(S)-Rh2E2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolism
Huang, Q., Zhang, H., Bai, L. P., Law, B. Y. K., Xiong, H., Zhou, X., Xiao, R., Qu, Y. Q., Mok, S. W. F., Liu, L. & Wong, V. K. W. Cell Death Dis. 2020. 11 (8): 621.

Downregulation of Hsa_circ_0000735 Inhibits the Proliferation, Migration, Invasion, and Glycolysis in Non-small-cell Lung Cancer by Targeting miR-940/BMPER Axis
Huang, W., Xu, X., Liu, M., Cui, W. & Peng, G. Onco Targets Ther. 2020. 13 8427-8439.

Romo1 Inhibition Induces TRAIL-Mediated Apoptosis in Colorectal Cancer
Jo, M. J., Kim, B. G., Park, S. H., Kim, H. J., Jeong, S., Kim, B. R., Kim, J. L., Na, Y. J., Jeong, Y. A., Yun, H. K., Kim, D. Y., Han, J., Heo, J. Y., Yoo, Y. D., Lee, D. H. & Oh, S. C. Cancers (Basel). 2020. 12 (9): 

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells
Kobylarz, M. J., Goodwin, J. M., Kang, Z. B., Annand, J. W., Hevi, S., O'Mahony, E., McAllister, G., Reece-Hoyes, J., Wang, Q., Alford, J., Russ, C., Lindeman, A., Beibel, M., Roma, G., Carbone, W., Knehr, J., Loureiro, J., Antczak, C., Wiederschain, D., Murphy, L. O., Menon, S. & Nyfeler, B. PLoS One. 2020. 15 (8): e0235551.

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche
Martinez-Reyes, I., Cardona, L. R., Kong, H., Vasan, K., McElroy, G. S., Werner, M., Kihshen, H., Reczek, C. R., Weinberg, S. E., Gao, P., Steinert, E. M., Piseaux, R., Budinger, G. R. S. and Chandel, N. S.
Nature. 2020 Sep, 585(7824):288-292.

S100A2 promotes glycolysis and proliferation via GLUT1 regulation in colorectal cancer
Li, C., Chen, Q., Zhou, Y., Niu, Y., Wang, X., Li, X., Zheng, H., Wei, T., Zhao, L. & Gao, H. FASEB J. 2020. 34 (10): 13333-13344.

CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis
Li, Z., Yao, H., Wang, S., Li, G. & Gu, X. J Exp Clin Cancer Res. 2020. 39 (1): 160.

Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation
Liu, F., Kalpage, H. A., Wang, D., Edwards, H., Huttemann, M., Ma, J., Su, Y., Carter, J., Li, X., Polin, L., Kushner, J., Dzinic, S. H., White, K., Wang, G., Taub, J. W. & Ge, Y. Cancers (Basel). 2020. 12 (9): 

Mitochondrion-Directed Nanoparticles Loaded with a Natural Compound and a microRNA for Promoting Cancer Cell Death via the Modulation of Tumor Metabolism and Mitochondrial Dynamics
Lo, Y. L., Wang, C. S., Chen, Y. C., Wang, T. Y., Chang, Y. H., Chen, C. J. & Yang, C. P. Pharmaceutics. 2020. 12 (8): 

LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1
Logotheti, S., Marquardt, S., Gupta, S. K., Richter, C., Edelhauser, B. A. H., Engelmann, D., Brenmoehl, J., Sohnchen, C., Murr, N., Alpers, M., Singh, K. P., Wolkenhauer, O., Heckl, D., Spitschak, A. & Putzer, B. M. Theranostics. 2020. 10 (21): 9620-9643.

MiR-5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer
Miao, Y., Li, Q., Sun, G., Wang, L., Zhang, D., Xu, H. & Xu, Z. Cancer Med. 2020. 9 (19): 7231-7243.

Loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma
Zhao, C., Wang, B., Liu, E. & Zhang, Z. Cell Commun Signal. 2020. 18 (1): 131.

Self-Maintaining CD103(+) Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses
Abd Hamid, M., Colin-York, H., Khalid-Alham, N., Browne, M., Cerundolo, L., Chen, J. L., Yao, X., Rosendo-Machado, S., Waugh, C., Maldonado-Perez, D., Bowes, E., Verrill, C., Cerundolo, V., Conlon, C. P., Fritzsche, M., Peng, Y. & Dong, T. Cancer Immunol Res. 2020. 8 (2): 203-216.

Targeting Mitochondria in Melanoma
Aminzadeh-Gohari, S., Weber, D. D., Catalano, L., Feichtinger, R. G., Kofler, B. & Lang, R. Biomolecules. 2020. 10 (10): 

Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice
Cao, D., Jia, Z., Wu, Y., Su, T., Zhao, D., Wu, M., Tsukamoto, T., Oshima, M., Jiang, J. & Cao, X. Life Sci. 2020. 263 118580.

Cardiovascular Research
An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility
Madsen, A., Hoppner, G., Krause, J., Hirt, M. N., Laufer, S. D., Schweizer, M., Tan, W. L. W., Mosqueira, D., Anene-Nzelu, C. G., Lim, I., Foo, R. S. Y., Eschenhagen, T. & Stenzig, J. Circulation. 2020. 142 (16): 1562-1578.

Cardioprotection by isosteviol derivate JC105: A unique drug property to activate ERK1/2 only when cells are exposed to hypoxia-reoxygenation
Mohammed Abdul, K. S., Rayadurgam, J., Faiz, N., Jovanovic, A. & Tan, W. J Cell Mol Med. 2020. 24 (18): 10924-10934.

Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries
Skofic Maurer, D., Zabini, D., Nagaraj, C., Sharma, N., Lengyel, M., Nagy, B. M., Frank, S., Klepetko, W., Gschwandtner, E., Enyedi, P., Kwapiszewska, G., Olschewski, H. & Olschewski, A. Cells. 2020. 9 (9): 

Downregulation of Hsa_circ_0000735 Inhibits the Proliferation, Migration, Invasion, and Glycolysis in Non-small-cell Lung Cancer by Targeting miR-940/BMPER Axis
Huang, W., Xu, X., Liu, M., Cui, W. & Peng, G. Onco Targets Ther. 2020. 13 8427-8439.

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
Helou, D. G., Shafiei-Jahani, P., Lo, R., Howard, E., Hurrell, B. P., Galle-Treger, L., Painter, J. D., Lewis, G., Soroosh, P., Sharpe, A. H. & Akbari, O. Nat Commun. 2020. 11 (1): 3998.

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury
Zhou, B., Magana, L., Hong, Z., Huang, L. S., Chakraborty, S., Tsukasaki, Y., Huang, C., Wang, L., Di, A., Ganesh, B., Gao, X., Rehman, J. & Malik, A. B. Nat Immunol. 2020. 21 (11): 1430-1443.

Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production
Atkinson, S. K., Morice, A. H. & Sadofsky, L. R. ERJ Open Res. 2020. 6 (4): 

Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes
Miao, S., Zhao, D., Wang, X., Ni, X., Fang, X., Yu, M., Ye, L., Yang, J., Wu, H., Han, X., Qu, L., Li, L., Lan, F., Shen, Z., Lei, W., Zhao, Z. A. & Hu, S. Theranostics. 2020. 10 (21): 9686-9701.

Laminin-221 Enhances Therapeutic Effects of Human-Induced Pluripotent Stem Cell-Derived 3-Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model
Samura, T., Miyagawa, S., Kawamura, T., Fukushima, S., Yokoyama, J. Y., Takeda, M., Harada, A., Ohashi, F., Sato-Nishiuchi, R., Toyofuku, T., Toda, K., Sekiguchi, K. & Sawa, Y. J Am Heart Assoc. 2020. 9 (16): e015841.

Studies on the effects of bone marrow stem cells on mitochondrial function and the alleviation of ARDS
Zhang, K., Gao, Y., Deng, Y., Zhou, X., Zhu, C., He, Z. & Lv, D. Mol Cell Biochem. 2020.

Pod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells
Lamb, T., Muthumalage, T. & Rahman, I. Toxicol Lett. 2020. 333 303-311.

Cell Physiology Research
Multi-organ metabolomics and lipidomics provide new insights into fat infiltration in the liver, muscle wasting and liver-muscle crosstalk following burn injury
Mert, S., Bulutoglu, B., Chu, C., Dylewski, M., Lin, F. M., Yu, Y. M., Yarmush, M. L., Sheridan, R. L. & Uygun, K. J Burn Care Res. 2020. 

The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes
Sweeney, M. A., Iakova, P., Maneix, L., Shih, F. Y., Cho, H. E., Sahin, E. & Catic, A. Sci Rep. 2020. 10 (1): 13942.

Mitochondrial energetic impairment in a patient with late-onset glutaric acidemia Type 2
Xiao, C., Astiazaran-Symonds, E., Basu, S., Kisling, M., Scaglia, F., Chapman, K. A., Wang, Y., Vockley, J. & Ferreira, C. R. Am J Med Genet A. 2020. 182 (10): 2426-2431.

Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation
Abreu, P., Serna, J. D. C., Munhoz, A. C. & Kowaltowski, A. J. Mech Ageing Dev. 2020. 192 111362.

Effects of PCB126 on Adipose-to-Muscle Communication in an in Vitro Model
Caron, A., Ahmed, F., Peshdary, V., Garneau, L., Atlas, E. & Aguer, C. Environ Health Perspect. 2020. 128 (10): 107002.

Mitochondrial Regulation of the 26S Proteasome
Meul, T., Berschneider, K., Schmitt, S., Mayr, C. H., Mattner, L. F., Schiller, H. B., Yazgili, A. S., Wang, X., Lukas, C., Schlesser, C., Prehn, C., Adamski, J., Graf, E., Schwarzmayr, T., Perocchi, F., Kukat, A., Trifunovic, A., Kremer, L., Prokisch, H., Popper, B., von Toerne, C., Hauck, S. M., Zischka, H. & Meiners, S. Cell Rep. 2020. 32 (8): 108059.

Mitochondrial and Metabolic Dynamics of Endometrial Stromal Cells During the Endometrial Cycle
Ryu, M. J., Seo, B. J., Choi, Y. J., Han, M. J., Choi, Y., Chung, M. K. & Do, J. T. Stem Cells Dev. 2020. 

Drug Discovery
SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling
Jia, J., Wang, Z., Zhang, M., Huang, C., Song, Y., Xu, F., Zhang, J., Li, J., He, M., Li, Y., Ao, G., Hong, C., Cao, Y., Chin, Y. E., Hua, Z. C. & Cheng, J. Sci Adv. 2020. 6 (35): eaaz5752.

CircRNA hsa_circRNA_0001776 inhibits proliferation and promotes apoptosis in endometrial cancer via downregulating LRIG2 by sponging miR-182
Jia, Y., Liu, M. & Wang, S. Cancer Cell Int. 2020. 20 412.

Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
Rawling, T., MacDermott-Opeskin, H., Roseblade, A., Pazderka, C., Clarke, C., Bourget, K., Wu, X., Lewis, W., Noble, B., Gale, P. A., O'Mara, M. L., Cranfield, C. & Murray, M. Chemical Science. 2020. 11 (47): 12677-12685.

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells
Kobylarz, M. J., Goodwin, J. M., Kang, Z. B., Annand, J. W., Hevi, S., O'Mahony, E., McAllister, G., Reece-Hoyes, J., Wang, Q., Alford, J., Russ, C., Lindeman, A., Beibel, M., Roma, G., Carbone, W., Knehr, J., Loureiro, J., Antczak, C., Wiederschain, D., Murphy, L. O., Menon, S. & Nyfeler, B. PLoS One. 2020. 15 (8): e0235551.

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer
Muhammad, N., Tan, C. P., Nawaz, U., Wang, J., Wang, F. X., Nasreen, S., Ji, L. N. & Mao, Z. W. Inorg Chem. 2020. 59 (17): 12632-12642.
Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition
Roca-Portoles, A., Rodriguez-Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O'Neill, K., Lemgruber, L., Luo, X. & Tait, S. W. G. Cell Death Dis. 2020. 11 (8): 616.
The metabolic effects of mirabegron are mediated primarily by beta3 -adrenoceptors
Tabrizi, L., Thompson, K., Mnich, K., Chintha, C., Gorman, A. M., Morrison, L., Luessing, J., Lowndes, N. F., Dockery, P., Samali, A. and Erxleben, A.
Mol Pharm. 2020 Aug 3, 17(8):3009-3023.
Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation
Vergnes, L., Lin, J. Y., Davies, G. R., Church, C. D. & Reue, K. J Biol Chem. 2020. 295 (44): 15054-15069.

Food & Nutritional Research

Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance
Liu, L., Li, T., Liao, Y., Wang, Y., Gao, Y., Hu, H., Huang, H., Wu, F., Chen, Y. G., Xu, S. & Fu, S. Cell Metab. 2020. 32 (4): 605-618 e7.

Chilling injury in pineapple fruit is related to mitochondrial antioxidative metabolism
Nukuntornprakit, O.-a., Luengwilai, K. & Siriphanich, J. Postharvest Biology and Technology. 2020. 170 111330.

Effects of fluorescent carbon dots from the baked lamb on energy and lipid metabolism
Zhang, L., Na, X., Lai, B., Song, Y., Wang, H. & Tan, M. Food Chem. 2021. 338 127832.

Selenoprotein V protects against endoplasmic reticulum stress and oxidative injury induced by pro-oxidants
Zhang, X., Xiong, W., Chen, L. L., Huang, J. Q. & Lei, X. G. Free Radic Biol Med. 2020. 160 670-679.

Hepatobiology Research
Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma
Turcios, L., Marti, F., Watt, D. S., Kril, L. M., Khurana, A., Chapelin, F., Liu, C., Zwischenberger, J. B., Evers, B. M. & Gedaly, R. Oncotarget. 2020. 11 (31): 3013-3024.

Loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma
Zhao, C., Wang, B., Liu, E. & Zhang, Z. Cell Commun Signal. 2020. 18 (1): 131.

Multi-organ metabolomics and lipidomics provide new insights into fat infiltration in the liver, muscle wasting and liver-muscle crosstalk following burn injury
Mert, S., Bulutoglu, B., Chu, C., Dylewski, M., Lin, F. M., Yu, Y. M., Yarmush, M. L., Sheridan, R. L. & Uygun, K. J Burn Care Res. 2020. 

Immunology Research
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
Helou, D. G., Shafiei-Jahani, P., Lo, R., Howard, E., Hurrell, B. P., Galle-Treger, L., Painter, J. D., Lewis, G., Soroosh, P., Sharpe, A. H. & Akbari, O. Nat Commun. 2020. 11 (1): 3998.

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
Moller, S. H., Mellergaard, M., Madsen, M., Bermejo, A. V., Jepsen, S. D., Hansen, M. H., Hogh, R. I., Aldana, B. I., Desler, C., Rasmussen, L. J., Sustarsic, E. G., Gerhart-Hines, Z., Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, H. H., Andresen, L. & Skov, S. Front Immunol. 2020. 11 1968.

Autophagic protein ATG5 controls antiviral immunity via glycolytic reprogramming of dendritic cells against respiratory syncytial virus infection
Xia, H., Li, S., Li, X., Wang, W., Bian, Y., Wei, S., Grove, S., Wang, W., Vatan, L., Liu, J. R., McLean, K., Rattan, R., Munkarah, A., Guan, J. L., Kryczek, I. & Zou, W. JCI Insight. 2020. 5 (18). 

Fasciola hepatica induces weak NETosis and low production of intra- and extracellular ROS in exposed bovine polymorphonuclear neutrophils
Peixoto, R., Silva, L. M. R., Lopez-Osorio, S., Zhou, E., Gartner, U., Conejeros, I., Taubert, A. & Hermosilla, C. Dev Comp Immunol. 2021. 114 103787.

Immunometabolic control of trained immunity
Riksen, N. P. & Netea, M. G. Mol Aspects Med. 2020. 100897.

Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI
Villegas-Mendez, A., Khandelwal, G., McGowan, L. M., Dookie, R. S., Haley, M. J., George, C., Sims, D., Lord, G. M., Sinclair, L. V., Jenner, R. G. & Couper, K. N. J Immunol. 2020. 205 (6): 1608-1619.

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
Tur, J., Pereira-Lopes, S., Vico, T., Marin, E. A., Munoz, J. P., Hernandez-Alvarez, M., Cardona, P. J., Zorzano, A., Lloberas, J. & Celada, A. Cell Rep. 2020. 32 (8): 108079.

Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
Villegas-Mendez, A., Khandelwal, G., McGowan, L. M., Dookie, R. S., Haley, M. J., George, C., Sims, D., Lord, G. M., Sinclair, L. V., Jenner, R. G. & Couper, K. N. J Immunol. 2020. 205 (6): 1608-1619.

T-cells produce acidic niches in lymph nodes to suppress their own effector functions
Wu, H., Estrella, V., Beatty, M., Abrahams, D., El-Kenawi, A., Russell, S., Ibrahim-Hashim, A., Longo, D. L., Reshetnyak, Y. K., Moshnikova, A., Andreev, O. A., Luddy, K., Damaghi, M., Kodumudi, K., Pillai, S. R., Enriquez-Navas, P., Pilon-Thomas, S., Swietach, P. & Gillies, R. J. Nat Commun. 2020. 11 (1): 4113.

Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis
Xia, H., Li, S., Li, X., Wang, W., Bian, Y., Wei, S., Grove, S., Wang, W., Vatan, L., Liu, J. R., McLean, K., Rattan, R., Munkarah, A., Guan, J. L., Kryczek, I. & Zou, W. JCI Insight. 2020. 5 (18). 

Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation
Yagi, Y., Kuwahara, M., Suzuki, J., Imai, Y. & Yamashita, M. Biochem Biophys Res Commun. 2020. 530 (2): 355-361.

Immune-evasive human islet-like organoids ameliorate diabetes
Yoshihara, E., O'Connor, C., Gasser, E., Wei, Z., Oh, T. G., Tseng, T. W., Wang, D., Cayabyab, F., Dai, Y., Yu, R. T., Liddle, C., Atkins, A. R., Downes, M. & Evans, R. M. Nature. 2020. 586 (7830): 606-611.

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury
Zhou, B., Magana, L., Hong, Z., Huang, L. S., Chakraborty, S., Tsukasaki, Y., Huang, C., Wang, L., Di, A., Ganesh, B., Gao, X., Rehman, J. & Malik, A. B. Nat Immunol. 2020. 21 (11): 1430-1443.

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure
Zhou, B., Wang, D. D., Qiu, Y., Airhart, S., Liu, Y., Stempien-Otero, A., O'Brien, K. D. & Tian, R. J Clin Invest. 2020. 130 (11): 6054-6063.

Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems
Abe, N., Nishihara, T., Yorozuya, T. & Tanaka, J. Cells. 2020. 9 (9) 

Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis
Awasthi, D., Nagarkoti, S., Sadaf, S., Chandra, T., Kumar, S. & Dikshit, M. Biochim Biophys Acta Mol Basis Dis. 2019. 1865 (12): 165542.

Self-Maintaining CD103(+) Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses
Abd Hamid, M., Colin-York, H., Khalid-Alham, N., Browne, M., Cerundolo, L., Chen, J. L., Yao, X., Rosendo-Machado, S., Waugh, C., Maldonado-Perez, D., Bowes, E., Verrill, C., Cerundolo, V., Conlon, C. P., Fritzsche, M., Peng, Y. & Dong, T. Cancer Immunol Res. 2020. 8 (2): 203-216.
Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone
Cheng, G., Hardy, M., Topchyan, P., Zander, R., Volberding, P., Cui, W. & Kalyanaraman, B. Sci Rep. 2020. 10 (1): 17872.

Infectious Disease Research
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasisKim, Y. J., Lee, S. H., Jeon, S. M., Silwal, P., Seo, J. Y., Hanh, B. T. B., Park, J. W., Whang, J., Lee, M. J., Heo, J. Y., Kim, S. H., Kim, J. M., Song, G. Y., Jang, J. & Jo, E. K. Virulence. 2020. 11 (1): 1225-1239.

Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans
Lev, S., Li, C., Desmarini, D., Liuwantara, D., Sorrell, T. C., Hawthorne, W. J. & Djordjevic, J. T. Pathogens. 2020. 9 (9): 

Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production
Atkinson, S. K., Morice, A. H. & Sadofsky, L. R. ERJ Open Res. 2020. 6 (4): 
In Vitro Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles
Bowman, E. R., Cameron, C., Richardson, B., Kulkarni, M., Gabriel, J., Kettelhut, A., Hornsby, L., Kwiek, J. J., Turner, A. N., Malvestutto, C., Bazan, J., Koletar, S. L., Doblecki-Lewis, S., Lederman, M. M., Cameron, M., Klatt, N. R., Lake, J. E. & Funderburg, N. T. Antimicrob Agents Chemother. 2020. 65 (1). 
Autophagic protein ATG5 controls antiviral immunity via glycolytic reprogramming of dendritic cells against respiratory syncytial virus infection
Oh, D. S., Park, J. H., Jung, H. E., Kim, H. J. & Lee, H. K. Autophagy. 2020. 1-17.
Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
Villegas-Mendez, A., Khandelwal, G., McGowan, L. M., Dookie, R. S., Haley, M. J., George, C., Sims, D., Lord, G. M., Sinclair, L. V., Jenner, R. G. & Couper, K. N. J Immunol. 2020. 205 (6): 1608-1619.

Mitochondrial Disease Research
Altered Expression Ratio of Actin-Binding Gelsolin Isoforms Is a Novel Hallmark of Mitochondrial OXPHOS Dysfunction
Garcia-Bartolome, A., Penas, A., Illescas, M., Bermejo, V., Lopez-Calcerrada, S., Perez-Perez, R., Marin-Buera, L., Dominguez-Gonzalez, C., Arenas, J., Martin, M. A. & Ugalde, C. Cells. 2020. 9 (9):

Pathogenic mutations reveal a role of RECQ4 in mitochondrial RNA:DNA hybrid formation and resolution
Chang, C. W., Xu, X., Li, M., Xin, D., Ding, L., Wang, Y. T. & Liu, Y. Sci Rep. 2020. 10 (1): 17033.

Neurobiology Research
Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice
Dematteis, G., Vydmantaite, G., Ruffinatti, F. A., Chahin, M., Farruggio, S., Barberis, E., Ferrari, E., Marengo, E., Distasi, C., Morkuniene, R., Genazzani, A. A., Grilli, M., Grossini, E., Corazzari, M., Manfredi, M., Lim, D., Jekabsone, A. & Tapella, L. Cell Death Dis. 2020. 11 (8): 645.

Methylglyoxal-Induced Dysfunction in Brain Endothelial Cells via the Suppression of Akt/HIF-1alpha Pathway and Activation of Mitophagy Associated with Increased Reactive Oxygen Species
Kim, D., Kim, K. A., Kim, J. H., Kim, E. H. & Bae, O. N. Antioxidants (Basel). 2020. 9 (9): 

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons
Kumar, M., Acevedo-Cintron, J., Jhaldiyal, A., Wang, H., Andrabi, S. A., Eacker, S., Karuppagounder, S. S., Brahmachari, S., Chen, R., Kim, H., Ko, H. S., Dawson, V. L. & Dawson, T. M. Stem Cell Reports. 2020. 15 (3): 629-645.

Dual effects of thyroid hormone on neurons and neurogenesis in traumatic brain injury
Lin, C., Li, N., Chang, H., Shen, Y., Li, Z., Wei, W., Chen, H., Lu, H., Ji, J. & Liu, N. Cell Death Dis. 2020. 11 (8): 671.

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities
Liu, Z., Ning, J., Zheng, X., Meng, J., Han, L., Zheng, H., Zhong, L., Chen, X. F., Zhang, X., Luo, H., Can, D., Xu, H. & Zhang, Y. W. Cell Death Dis. 2020. 11 (8): 678.

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival
Muraleedharan, R., Gawali, M. V., Tiwari, D., Sukumaran, A., Oatman, N., Anderson, J., Nardini, D., Bhuiyan, M. A. N., Tkac, I., Ward, A. L., Kundu, M., Waclaw, R., Chow, L. M., Gross, C., Rao, R., Schirmeier, S. & Dasgupta, B. Cell Rep. 2020. 32 (9): 108092.

Metabolic alterations in Parkinson's disease astrocytes
Perez, M. J., Ivanyuk, D., Panagiotakopoulou, V., Di Napoli, G., Kalb, S., Brunetti, D., Al-Shaana, R., Kaeser, S. A., Fraschka, S. A., Jucker, M., Zeviani, M., Viscomi, C. and Deleidi, M.
Mol Psychiatry. 2020 Jul 7, [epub ahead of print]

Moderate static magnetic fields enhance antitumor CD8(+) T cell function by promoting mitochondrial respiration
Zhu, X., Liu, Y., Cao, X., Liu, H., Sun, A., Shen, H., Zhao, J., Li, R., Wu, L., Fang, Z., Wang, H. & Zhai, Q. Sci Rep. 2020. 10 (1): 14519.

Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model
Alcover-Sanchez, B., Garcia-Martin, G., Escudero-Ramirez, J., Gonzalez-Riano, C., Lorenzo, P., Gimenez-Cassina, A., Formentini, L., de la Villa-Polo, P., Pereira, M. P., Wandosell, F. & Cubelos, B. Glia. 2021. 69 (3): 619-637.

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity
Chatterjee, A., Eshwaran, R., Poschet, G., Lomada, S., Halawa, M., Wilhelm, K., Schmidt, M., Hammes, H. P., Wieland, T. & Feng, Y. Cells. 2020. 9 (10).

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche
Underwood, E., Redell, J. B., Zhao, J., Moore, A. N. and Dash, P. K.
Sci Rep. 2020 Aug 6, 10(1):13179.

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation
Xu, X., Wang, W., Wang, Z., Lv, J., Xu, X., Xu, J., Yang, J., Zhu, X., Lu, Y., Duan, W., Huang, X., Wang, J., Zhou, J. and Shen, X.
Diabetes. 2020 Sep, 69(9):1974-1988.

Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems
Abe, N., Nishihara, T., Yorozuya, T. & Tanaka, J. Cells. 2020. 9 (9) 

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids
Arzua, T., Yan, Y., Jiang, C., Logan, S., Allison, R. L., Wells, C., Kumar, S. N., Schafer, R. & Bai, X. Transl Psychiatry. 2020. 10 (1): 347.
Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells
Yang, P., Shao, Z., Besley, N. A., Neal, S. E., Buehne, K. L., Park, J., Karageozian, H., Karageozian, V., Ryde, I. T., Meyer, J. N. & Jaffe, G. J. Invest Ophthalmol Vis Sci. 2020. 61 (10): 35.

Obesity, Diabetes & Metabolic Diseases
The metabolic effects of mirabegron are mediated primarily by beta3 -adrenoceptors
Dehvari, N., Sato, M., Bokhari, M. H., Kalinovich, A., Ham, S., Gao, J., Nguyen, H. T. M., Whiting, L., Mukaida, S., Merlin, J., Chia, L. Y., Wootten, D., Summers, R. J., Evans, B. A., Bengtsson, T. & Hutchinson, D. S. Pharmacol Res Perspect. 2020. 8 (5): e00643.

Hepatic lipids promote liver metastasis
Li, Y., Su, X., Rohatgi, N., Zhang, Y., Brestoff, J. R., Shoghi, K. I., Xu, Y., Semenkovich, C. F., Harris, C. A., Peterson, L. L., Weilbaecher, K. N., Teitelbaum, S. L. & Zou, W. JCI Insight. 2020. 5 (17): 

Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation
Vergnes, L., Lin, J. Y., Davies, G. R., Church, C. D. & Reue, K. J Biol Chem. 2020. 295 (44): 15054-15069.

Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance
Wang, C., Chao, Y., Xu, W., Liu, Z., Wang, H. & Huang, K. Redox Biol. 2020. 37 101688.

Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
Zhang, L., Avery, J., Yin, A., Singh, A. M., Cliff, T. S., Yin, H. & Dalton, S. Cell Stem Cell. 2020. 27 (5): 784-797 e11.

Effects of PCB126 on Adipose-to-Muscle Communication in an in Vitro Model
Caron, A., Ahmed, F., Peshdary, V., Garneau, L., Atlas, E. & Aguer, C. Environ Health Perspect. 2020. 128 (10): 107002.

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Chareyron, I., Christen, S., Moco, S., Valsesia, A., Lassueur, S., Dayon, L., Wollheim, C. B., Santo Domingo, J. & Wiederkehr, A. Diabetologia. 2020. 63 (12): 2628-2640.

Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance
Liu, L., Li, T., Liao, Y., Wang, Y., Gao, Y., Hu, H., Huang, H., Wu, F., Chen, Y. G., Xu, S. & Fu, S. Cell Metab. 2020. 32 (4): 605-618 e7.

Immune-evasive human islet-like organoids ameliorate diabetes
Yoshihara, E., O'Connor, C., Gasser, E., Wei, Z., Oh, T. G., Tseng, T. W., Wang, D., Cayabyab, F., Dai, Y., Yu, R. T., Liddle, C., Atkins, A. R., Downes, M. & Evans, R. M. Nature. 2020. 586 (7830): 606-611.

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity
Chatterjee, A., Eshwaran, R., Poschet, G., Lomada, S., Halawa, M., Wilhelm, K., Schmidt, M., Hammes, H. P., Wieland, T. & Feng, Y. Cells. 2020. 9 (10).

Review Papers
A review on qualifications and cost effectiveness of induced pluripotent stem cells (IPSCs)-induced cardiomyocytes in drug screening tests
Malihi, G., Nikoui, V. & Elson, E. L. Arch Physiol Biochem. 2020. 1-12.

Immunometabolic control of trained immunity
Riksen, N. P. & Netea, M. G. Mol Aspects Med. 2020. 100897.
Transient-doped organic electrochemical transistors working in current-enhancing mode as sensing devices for low concentration of oxygen dissolved in solution
Decataldo, F., Gualandi, I., Tessarolo, M., Scavetta, E. & Fraboni, B. APL Materials. 2020. 8 (9): 091103.

Stem Cell Biology
Mitochondrial Regulation of the 26S Proteasome
Meul, T., Berschneider, K., Schmitt, S., Mayr, C. H., Mattner, L. F., Schiller, H. B., Yazgili, A. S., Wang, X., Lukas, C., Schlesser, C., Prehn, C., Adamski, J., Graf, E., Schwarzmayr, T., Perocchi, F., Kukat, A., Trifunovic, A., Kremer, L., Prokisch, H., Popper, B., von Toerne, C., Hauck, S. M., Zischka, H. & Meiners, S. Cell Rep. 2020. 32 (8): 108059.

Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes
Miao, S., Zhao, D., Wang, X., Ni, X., Fang, X., Yu, M., Ye, L., Yang, J., Wu, H., Han, X., Qu, L., Li, L., Lan, F., Shen, Z., Lei, W., Zhao, Z. A. & Hu, S. Theranostics. 2020. 10 (21): 9686-9701.

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
Oizel, K., Yang, C., Renoult, O., Gautier, F., Do, Q. N., Joalland, N., Gao, X., Ko, B., Vallette, F., Ge, W. P., Paris, F., DeBerardinis, R. J. & Pecqueur, C. Cancer Metab. 2020. 8 9.

Mitochondrial and Metabolic Dynamics of Endometrial Stromal Cells During the Endometrial Cycle
Ryu, M. J., Seo, B. J., Choi, Y. J., Han, M. J., Choi, Y., Chung, M. K. & Do, J. T. Stem Cells Dev. 2020. 

Laminin-221 Enhances Therapeutic Effects of Human-Induced Pluripotent Stem Cell-Derived 3-Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model
Samura, T., Miyagawa, S., Kawamura, T., Fukushima, S., Yokoyama, J. Y., Takeda, M., Harada, A., Ohashi, F., Sato-Nishiuchi, R., Toyofuku, T., Toda, K., Sekiguchi, K. & Sawa, Y. J Am Heart Assoc. 2020. 9 (16): e015841.

Studies on the effects of bone marrow stem cells on mitochondrial function and the alleviation of ARDS
Zhang, K., Gao, Y., Deng, Y., Zhou, X., Zhu, C., He, Z. & Lv, D. Mol Cell Biochem. 2020.

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids
Arzua, T., Yan, Y., Jiang, C., Logan, S., Allison, R. L., Wells, C., Kumar, S. N., Schafer, R. & Bai, X. Transl Psychiatry. 2020. 10 (1): 347.

An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility
Madsen, A., Hoppner, G., Krause, J., Hirt, M. N., Laufer, S. D., Schweizer, M., Tan, W. L. W., Mosqueira, D., Anene-Nzelu, C. G., Lim, I., Foo, R. S. Y., Eschenhagen, T. & Stenzig, J. Circulation. 2020. 142 (16): 1562-1578.

Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation
Abreu, P., Serna, J. D. C., Munhoz, A. C. & Kowaltowski, A. J. Mech Ageing Dev. 2020. 192 111362.

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons
Kumar, M., Acevedo-Cintron, J., Jhaldiyal, A., Wang, H., Andrabi, S. A., Eacker, S., Karuppagounder, S. S., Brahmachari, S., Chen, R., Kim, H., Ko, H. S., Dawson, V. L. & Dawson, T. M. Stem Cell Reports. 2020. 15 (3): 629-645.

Dual effects of thyroid hormone on neurons and neurogenesis in traumatic brain injury
Lin, C., Li, N., Chang, H., Shen, Y., Li, Z., Wei, W., Chen, H., Lu, H., Ji, J. & Liu, N. Cell Death Dis. 2020. 11 (8): 671.
Metabolic alterations in Parkinson's disease astrocytes
Sonninen, T. M., Hamalainen, R. H., Koskuvi, M., Oksanen, M., Shakirzyanova, A., Wojciechowski, S., Puttonen, K., Naumenko, N., Goldsteins, G., Laham-Karam, N., Lehtonen, M., Tavi, P., Koistinaho, J. & Lehtonen, S. Sci Rep. 2020. 10 (1): 14474.

Techniques & Methods
Transient-doped organic electrochemical transistors working in current-enhancing mode as sensing devices for low concentration of oxygen dissolved in solution
Decataldo, F., Gualandi, I., Tessarolo, M., Scavetta, E. & Fraboni, B. APL Materials. 2020. 8 (9): 091103.

Single-cell metabolic profiling of human cytotoxic T cells
Hartmann, F. J., Mrdjen, D., McCaffrey, E., Glass, D. R., Greenwald, N. F., Bharadwaj, A., Khair, Z., Verberk, S. G. S., Baranski, A., Baskar, R., Graf, W., Van Valen, D., Van den Bossche, J., Angelo, M. & Bendall, S. C. Nat Biotechnol. 2020. 

Toxicology Research
Pod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells
Lamb, T., Muthumalage, T. & Rahman, I. Toxicol Lett. 2020. 333 303-311.

Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells
Yang, P., Shao, Z., Besley, N. A., Neal, S. E., Buehne, K. L., Park, J., Karageozian, H., Karageozian, V., Ryde, I. T., Meyer, J. N. & Jaffe, G. J. Invest Ophthalmol Vis Sci. 2020. 61 (10): 35.

Effects of fluorescent carbon dots from the baked lamb on energy and lipid metabolism
Zhang, L., Na, X., Lai, B., Song, Y., Wang, H. & Tan, M. Food Chem. 2021. 338 127832.